- Malattie cardiache
- Parkinson
- GvHd
- Lesioni spinali
- Ictus cerebrali
- Degenerazione dei nuclei della base (MSA, PSP, Huntington, Tourette)
- Alzheimer
- Malattie autoimmuni
- Danni renali
- Sclerosi multipla
- Diabete Mellito di tipo I
- Osteogenesi Imperfetta e difetti osseo-cartilaginei
- Lupus eritematoso sistemico
- Transplantologia
3) Cellule staminali nello di sviluppo di protocolli terapeutici per la malattia di Parkinson: una prospettiva
J Cell Biochem. 2008 Dec 1;105(5):1153-60.
Stem cells in development of therapeutics for Parkinson‘s disease: a perspective.
Xi J, Zhang SC.
Department of Human Anatomy and Histology, Institute of Stem Cells and Tissue Engineering, Fudan University Shanghai Medical School, Shanghai, China.
Using Parkinson‘s disease as a prototype of neurodegenerative diseases, we propose applications of human stem cells in the development of therapeutics for neurodegenerative diseases. First, in vitro differentiation of human stem cells offers a versatile model for dissecting molecular interactions underlying human dopamine (DA) neuron specification, which may form a foundation for instigating regeneration of DA neurons from progenitors that reside in the brain. Second, stem cells derived from diseased cells or through genetic modification can serve as a platform for unraveling biochemical processes that lead to the cellular pathogenesis of degeneration. This may in turn serve as a template for identifying or developing therapeutics for slowing, stopping, or reversing the disease process. And finally, stem cells, particularly those induced from patients’ own cells, provide a reliable source of DA neurons for cell-based therapy.
