- Malattie cardiache
- Parkinson
- GvHd
- Lesioni spinali
- Ictus cerebrali
- Degenerazione dei nuclei della base (MSA, PSP, Huntington, Tourette)
- Alzheimer
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- Danni renali
- Sclerosi multipla
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- Osteogenesi Imperfetta e difetti osseo-cartilaginei
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Un blog dedicato alle cellule staminali e al loro utilizzo terapeutico.
Interviste, analisi e articoli scritti dai sostenitori della Stamina Foundation.
Su quali patologie opera la medicina rigenerativa?
6) Cellule staminali mesenchimali e rigenerazione della cartilagine in situ
J Intern Med. 2009 Oct;266(4):390-405.
Mesenchymal stem cells and cartilage in situ regeneration.
Richter W.
Department of Experimental Orthopaedics, Orthopaedic University Hospital, Heidelberg, Germany. [email protected]
Abstract
Cartilage repair is a very successful pioneering area of regenerative medicine in which techniques of in situ regeneration and cell and tissue transplantation dominate over cell-free approaches to generate durable neocartilage. This review concentrates on advantages and limitations of mesenchymal stem cell (MSC)-based cartilage repair strategies induced by marrow stimulation. Detailed knowledge on the biology of MSC will be discussed in light of the requirements for MSC recruitment, retention, proliferation and chondrogenic differentiation. An improved microenvironment with timely correlated signals from biomaterials, growth factors, proteases, adjacent cartilage and subchondral bone may be key to a third generation of techniques to regenerate hyaline cartilage.
