6) Trapianto di midollo osseo autologo e terapia con ossigeno iperbarico in pazienti con la tromboangite oblierante

Autologous bone marrow transplantation and hyperbaric oxygen therapy for patients with thromboangiitis obliterans.


Saito S, Nishikawa K, Obata H, Goto F.
Department of Anesthesiology, Gunma University Graduate School of Medicine, Maebashi, Japan. [email protected] -u.ac.jp


Many patients suffering from severe ischemic limb disease inevitably experience amputation, despite intensive therapies. Sympathectomy and hyperbaric oxygen therapy are optional therapies for patients with peripheral circulation disorders. Recently, several clinical studies have established that implantation of bone marrow-mononuclear cells into ischemic limbs increases collateral vessel formation. In the present study, autologous implantation of bone marrow-mononuclear cells was prescribed to 7 patients with ischemic limbs because of peripheral arterial disease. Although the extent of the improvement was not consistent among the 7 cases, all of the patients experienced some improvement in their symptoms. Transcutaneous oxygen partial pressure measured in a hyperbaric chamber increased in 5 patients. No side effects were observed. In conclusion, combined use of autologous bone marrow transplantation and hyperbaric oxygen therapy may be safe and effective for achievement of therapeutic angiogenesis.


Angiology. 2007 Aug-Sep;58(4):429-34. Epub 2007 Jul 24